Key result
Long-term LDL apheresis linked to lower cholesterol, fewer cardiac events, and less coronary revascularization.
Why the study?
The impact of low-density lipoprotein apheresis on aortic and coronary angiographic outcomes in children with severe genetic hypercholesterolemia was not well established.
Does low-density lipoprotein apheresis prevent cardiovascular events and coronary lesion progression in children with severe genetic hypercholesterolemia?
Cohort (n=11)
No
Does low-density lipoprotein apheresis prevent cardiovascular events and coronary lesion progression in children with severe genetic hypercholesterolemia?
p-value: p=<=0.001
Long-term LDL apheresis in children with severe genetic hypercholesterolemia significantly reduces LDL levels and prevents the development of new aortic and coronary lesions or clinical cardiovascular events.
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Supports LDL apheresis in pediatric genetic hypercholesterolemia; leaves open confirmation by randomized trials.
Stefanutti et al. (2009) conducted a cohort in Severe genetic hypercholesterolemia (n=11). Low-density lipoprotein apheresis (LDLa) vs. Baseline (pre-treatment) was evaluated on Total cholesterol and LDL cholesterol levels, clinical cardiovascular events, and angiographic findings (p=<=0.001). Low-density lipoprotein apheresis significantly reduced total and LDL cholesterol levels (P<=0.001) and prevented cardiac events and coronary revascularization over 2 to 17 years.
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