Sulthiame was investigated as a tranquillizer in a double-blind trial on 34 severely subnormal patients with disturbed behaviour. A special rating scale was used by nurses for the assessment of behavioural changes in hyperactivity, aggressiveness, destructiveness and anti-sociability. The results showed that sulthiame was significantly effective in reducing disturbed behaviour in general, and aggressiveness and hyperactivity in particular. Only one case of hyperpnoea was observed, in an epileptic patient.
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Al-Kaisi et al. (1974) studied this question.