Key result
Wilson's disease linked to major musculoskeletal abnormalities in ~29% of patients over 21.
Why the study?
Unusual osteoarticular manifestations in Wilson's disease are infrequently recognized and require clinical and radiographic characterization.
What are the clinical and radiographic osteoarticular changes in patients with Wilson's disease?
Observational (n=17)
What are the clinical and radiographic osteoarticular changes in patients with Wilson's disease?
Adults with Wilson's disease may exhibit unusual wrist and knee osteoarticular changes, including calcified loose bodies and premature degenerative arthritis.
May prompt Wilson's disease evaluation in young adults with atypical arthritis; case reports leave prevalence and mechanisms open.
The musculoskeletal system of 17 patients with known Wilson's disease was studied clinically and radiographically. Major abnormalities were seen only in 5 patients over 21 years of age. Multiple calcified loose bodies at the wrists were present in 4, premature degenerative arthritis at the knees with chondromalacia patellae in 4 and chondrocalcinosis at the knees in 2. Mild demineralization was seen at all ages and was present in 9 patients. These unusual wrist and knee changes are infrequently recognized manifestations of Wilson's disease in the adult.
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Feller et al. (1972) conducted an observational in Wilson's disease (n=17). Wilson's disease was evaluated on Musculoskeletal abnormalities. Wilson's disease was associated with major musculoskeletal abnormalities in 5 of 17 patients over 21 years of age, including calcified loose bodies at the wrists and premature degenerative arthritis.
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