Key result
Continuous IV ketamine does not affect functional residual capacity vs awake state in young children.
Why the study?
The effect of ketamine on functional residual capacity in young children prior to elective surgery was not established.
Does ketamine affect functional residual capacity in young children?
Observational (n=9)
Does ketamine affect functional residual capacity in young children?
Absolute Event Rate: 411% vs 392%
Ketamine by continuous intravenous infusion does not affect resting lung volume (functional residual capacity) in young children.
May support ketamine without FRC concern in young children; leaves open broader applicability and outcome impact.
The effect of ketamine on the functional residual capacity (FRC) was measured in nine ASA class I children prior to elective surgery. FRC was determined by the closed-circuit helium dilution method on the day prior to surgery in the awake state and also following induction of anesthesia on the day of the operation. Anesthesia consisted of ketamine by continuous intravenous infusion following preanesthetic sedation with atropine and triclofos or flunitrazepam. There were no significant differences in FRC between the measurements in the awake state and anesthetized (392 +/- 43 SEM ml, and 411 +/- 53 SEM ml, respectively), and the authors conclude that ketamine does not affect resting lung volume in young children.
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Shulman et al. (1985) conducted an observational in ASA class I children prior to elective surgery (n=9). Ketamine vs. Awake state was evaluated on Functional residual capacity (FRC). Ketamine by continuous intravenous infusion did not significantly affect functional residual capacity compared to the awake state in young children (411 vs 392 ml).
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