Key result
Vagotomy increases ischemic VT in a canine model, linked to prolonged ΔERP.
Why the study?
Little is known concerning the mechanisms responsible for ventricular tachycardia during myocardial ischemia and reperfusion and the effects of the autonomic nervous system on ventricular tachycardia.
Does autonomic denervation affect the incidence of ventricular tachycardia during myocardial ischemia and reperfusion in a canine model?
Does autonomic denervation affect the incidence of ventricular tachycardia during myocardial ischemia and reperfusion in a canine model?
In a canine model, vagotomy increased the incidence of ventricular tachycardia during myocardial ischemia, suggesting a protective role of vagal tone against ischemic arrhythmias.
Vagal tone may protect against ischemic VT in canines; hypothesis-generating for autonomic modulation in patients, pending clinical validation.
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Yoo et al. (2001) studied Myocardial ischemia and reperfusion (n=32). Autonomic denervation (stellectomy, vagotomy, or both) vs. Intact autonomic neural innervation was evaluated on Incidence of ventricular tachycardia and effective refractory period dispersion (ΔERP) during ischemia (p=<0.05). In a canine model, vagotomy significantly increased the incidence of ventricular tachycardia during ischemia compared to controls, and prolonged ΔERP was associated with ventricular tachycardia.
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