Cortical brain entropy architecture reveals multidimensional structure of schizophrenia

Schizophrenia is a multidimensional psychiatric disorder lacking a unifying systems-level framework. We introduce a cortical brain entropy architecture that characterizes the spatial and hierarchical organization of functional entropy across the cerebral cortex. In large-scale neuroimaging data, this architecture differentiates schizophrenia from health and captures multidimensional network variation. Entropy alterations follow structured cortical organization, revealing coordinated disruptions within association networks. These findings identify cortical brain entropy architecture as a compact systems-level marker of schizophrenia heterogeneity and establish a quantitative link between macroscale cortical entropy and clinical symptom dimensions.