Nonsteroidal Anti-inflammatory Drugs and Acute Cortical Necrosis

Letters and Corrections1 August 1986Nonsteroidal Anti-inflammatory Drugs and Acute Cortical NecrosisPAUL D. SCHNEIDER, M.D.PAUL D. SCHNEIDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-303_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nonsteroidal anti-inflammatory drugs are associated with various nephrologic syndromes, most of which are self-limiting when therapy with the drug is stopped (1). Chronic renal failure with interstitial fibrosis or papillary necrosis has been reported previously (2). The two cases reported here indicate that acute cortical necrosis with irreversible renal failure may also be related to nonsteroidal anti-inflammatory drugs.Patient 1: A 73-year-old woman became acutely ill with abdominal pain and nausea, without vomiting, diarrhea, fever, or symptomatic hypotension. She complained of decreased urine volume within 6 hours of the onset of her illness. She was hospitalized 12...References1. CLIVE D and STOFF J. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1984;310:563-72. CrossrefMedlineGoogle Scholar2. ADAMS D, MICHAEL J, BACON P, HOWIE A, MCCONKEY B, and ADU D. Non-steroidal anti-inflammatory drugs and renal failure. Lancet. 1986;1:57-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL D. SCHNEIDER, M.D.Affiliations: Internal Medicine Associates Inc. P.S.; Tacoma, WA 98405 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNaproxen induced acute interstitial nephritis with renal cortical necrosisIbuprofenToxic NephropathyVascular causes of renal failureAcute Renal Cortical Necrosis—A Study of 113 PatientsNonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal DiseaseDale P. Sandler, PhD, F. Rebecca Burr, MS, Clarice R. Weinberg, PhDDrugs and the KidneySouthwestern Internal Medicine Conference: Analgesic NephropathyAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 August 1986Volume 105, Issue 2 Page: 303-304 Keywords Drug therapy Drugs Fevers Fibrosis Hypotension Nausea Necrosis Renal failure Urine Vomiting ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...