Key result
Model-based ADMM methods for magnetic resonance elastography improve contrast-to-noise and signal-to-noise ratios versus existing methods.
Why the study?
Existing methods for shear modulus imaging in magnetic resonance elastography require preprocessing steps like bandpass filtering and may have slower convergence or sensitivity to initialization.
The proposed ADMM-based iterative methods for magnetic resonance elastography improve contrast-to-noise and signal-to-noise ratios without requiring bandpass filtering.
Model-based iterative MRE methods may refine modulus estimation; leaves open clinical utility pending validation studies.
We introduce two model-based iterative methods to obtain shear modulus images of tissue using magnetic resonance elastography. The first method jointly finds the displacement field that best fits tissue displacement data and the corresponding shear modulus. The displacement satisfies a viscoelastic wave equation constraint, discretized using the finite element method. Sparsifying regularization terms in both shear modulus and displacement are used in the cost function minimized for the best fit. The second method extends the first method for multifrequency tissue displacement data. The formulated problems are bi-convex. Their solution can be obtained iteratively by using the alternating direction method of multipliers. Sparsifying regularizations and the wave equation constraint filter out sensor noise and compressional waves. Our methods do not require bandpass filtering as a preprocessing step and converge fast irrespective of the initialization. We evaluate our new methods in multiple in silico and phantom experiments, with comparisons with existing methods, and we show improvements in contrast to noise and signal-to-noise ratios. Results from an in vivo liver imaging study show elastograms with mean elasticity comparable to other values reported in the literature.
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Mohammed et al. (2022) studied this question. Model-based iterative methods using ADMM for magnetic resonance elastography vs. Existing methods was evaluated on Contrast-to-noise and signal-to-noise ratios in shear modulus images. Model-based iterative methods using the alternating direction method of multipliers for magnetic resonance elastography improved contrast-to-noise and signal-to-noise ratios compared to existing methods.
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