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September 17, 2026Clinical and Experimental Ophthalmology

The Role of the MYOC Gene in Primary Open Angle Glaucoma in Ethiopia

Girum Gessesse Patricia Graham Lemlem Tamrat Tigabu Matiyas Engida Gebreselase Johanna L. Jones James Muecke Kathryn P. Burdon

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Key Points

To evaluate the genetic role and spectrum of MYOC gene variants in individuals with primary open angle glaucoma in Ethiopia.
Evaluated MYOC variants in an Ethiopian cohort using disease-specific variant curation guidelines.
Benchmarked identified variants against current ClinVar classifications and previously reported causative variants in populations of African descent.
Identified several MYOC variants classified as variants of uncertain significance within the Ethiopian cohort.
Reclassified previously reported causative African-descent MYOC variants according to updated variant curation criteria.

Implication

Genetic analysis reveals MYOC gene variants in Ethiopian open angle glaucoma, highlighting the need for population-specific clinical curation.

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Cite This Study

Gessesse et al. (2026) studied this question.

synapsesocial.com/papers/6aad0afede0393d728b894b4 https://doi.org/10.1111/ceo.70169

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Absence of Glaucoma in Tg-<i>MYOC<sup>Y437H</sup></i> Mice of Diverse Genetic Backgrounds2025 · 1 citations
2Disease Modeling of Myocilin Mutation Dependent Normal Tension Glaucoma: Human Retinal Ganglion Cell Susceptibility to UPR and mTOR SignalingOriginal Research · 2026 · 1 citations
3Socioeconomic and Environmental Factors Associated with Glaucoma in an African Ancestry Population: Findings from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study2024
4Exploratory Analysis of Glaucoma-Associated SNPs in a Colombian Cohort Highlights Potential Involvement of Oxidative, Vascular, and Neurodegenerative PathwaysOriginal Research · 2026
5Genetic variants through exome sequencing in Spanish patients affected by primary congenital glaucoma and juvenile open-angle glaucomaOriginal Research · 2025

More related papers

Multi-ancestry genome-wide association study in all of Us for primary open-angle glaucoma2026
Endophenotype Guided Genome-Wide Association Study to Enhance Genetic Risk Prediction of Primary Open-Angle Glaucoma in African Ancestry Populations2025
Clinical Implications of the Novel Genetic Polymorphism Associated With Retinal Vein Occlusion: The East Asian GWAS Survey in a Single-Center Taiwanese Cohort2026

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