Effects of time-restricted eating in early-stage Huntington’s disease: a pilot study

Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington’s disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and activity recommendations, in 20 individuals with early-stage HD. We show that TRE is feasible, well tolerated and associated with favourable changes in clinical measures of HD and plasma neurofilament light levels. Overall, these results support the need for further investigation of TRE as a potential lifestyle intervention in HD. A 12-week pilot study suggests that time-restricted eating is well tolerated and associated with favourable clinical outcomes in individuals with early-stage Huntington’s disease.