showed a discordant association with the CD4⁺/CD8⁺ ratio in the brain (negative) and spleen (positive). Furthermore, CD8⁺ T cells correlated with microbiota composition variation more strongly than strain, age, and sex. Together, these findings link the gut microbiota to age-dependent immune remodeling in the brain and imply that altered microbial communities could influence pro-inflammatory T-cell responses, thereby contributing to accelerated brain aging.
No takes yet. Share an insight, caveat, or question.
Peschke et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: