What question did this study set out to answer?

To develop a bottom-up synthetic approach for creating uniform hollow rare-earth silicate nanospheres for controlled drug release and X-ray-induced photodynamic therapy.

September 18, 2026Inorganic Chemistry

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

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Authors

WZWeijun ZhaoSun Yat-sen University RZRui ZouSouthwest Jiaotong University XYXujiang YuEast China University of Science and Technology

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Implication

Experimental study demonstrates synthesis of hollow rare-earth silicate nanospheres in cancer cell models, highlighting dual chemo- and photodynamic therapy potential.

Key Points

To develop a bottom-up synthetic approach for creating uniform hollow rare-earth silicate nanospheres for controlled drug release and X-ray-induced photodynamic therapy.
Regulated precursor nucleation rates and particle dimensions by introducing an optimized volume of 1-propanol to alter reaction medium dielectric constant and surface tension.
Triggered the Kirkendall effect via high-temperature annealing, using unequal interdiffusion between rare-earth and silicon atoms across phase boundaries to generate hollow internal cavities.
Evaluated drug loading and therapeutic efficacy using doxorubicin (DOX) for acid-sensitive chemotherapy and rose bengal (RB) for X-ray-activated singlet oxygen generation in vitro.
Thermal treatment and atomic interdiffusion yielded hollow nanospheres featuring internal voids of approximately 50 nm suitable for cargo encapsulation.
DOX-loaded nanospheres demonstrated acid-responsive drug release and induced pronounced cytotoxicity.
RB-loaded nanospheres generated singlet oxygen upon X-ray irradiation, successfully triggering cancer cell death.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6aad0bc6de0393d728b8a4c0 https://doi.org/10.1021/acs.inorgchem.6c02872

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Implication

Experimental study demonstrates synthesis of hollow rare-earth silicate nanospheres in cancer cell models, highlighting dual chemo- and photodynamic therapy potential.

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

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Implication

Key Points

Cite This Study

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

Discussion

Member takes

Implication

Key Points

Cite This Study

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