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September 18, 2026Seminars in Speech and Language

Word-Form and Lemma Dependency Networks of Connected Speech in Probable Alzheimer's Disease: Morphological Impacts on Syntactic Topological Metrics

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Authors

HSHongyan Shi

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Overview

Case-control study reveals altered speech network topology in probable Alzheimer's disease, indicating potential quantitative syntactic biomarkers for cognitive impairment.

Key Points

  • To examine how morphological inflections shape syntactic network topology by comparing word-form and lemma networks derived from connected speech in individuals with probable Alzheimer's disease and healthy controls.
  • Gathered spontaneous language samples via the Cookie Theft picture description task from 68 individuals with probable Alzheimer's disease and 68 healthy controls.
  • Constructed word-form and lemma dependency networks for each participant and calculated topological metrics including node and edge counts, average degree, density, clustering coefficients, and path length.
  • Both groups exhibited small-world network properties, but only healthy control networks adhered to scale-free rules, whereas patient networks deviated slightly.
  • Healthy controls demonstrated greater node and edge counts, whereas patient networks showed higher density and clustering coefficients, with significant topological differences displaying modest effect sizes (r = 0.21–0.29).
  • Intergroup differences in average degree were restricted to lemma networks (higher in controls), while average path length and network diameter were similar across groups.

Cite This Study

Hongyan Shi (2026) studied this question.

synapsesocial.com/papers/6aad0bfcde0393d728b8a868https://doi.org/10.1055/a-2954-9654
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphological processing in Alzheimer’s disease2025
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  3. 3Language network disruption in patients with Lewy body diseases2026
  4. 4Linguistic changes in neurodegenerative diseases relate to clinical symptoms2024 · 23 citations
  5. 5Dependency Grammar Approach to the Syntactic Complexity in the Discourse of Alzheimer Patients2025 · 2 citations