From bench to bedside: Colistin nephrotoxicity and vitamin E

oxidative stress have a role [24,25].Based on these data we thought to conduct a randomized trial to assess alpha-tocopherol effect on colistin nephrotoxicity in Loghman-Hakim hospital, a referral tertiary teaching medical center.Patients who are candidate to receive colistin to treat infections caused by multi-drug resistance gram negative bacillus are randomly assigned to receive 400 mg vitamin E in form of alpha tocopherol per day concomitantly by colistin or receive colistin alone.The trial is registered in the Iranian Registry on Clinical Trials by the code of IRCT20130917014693N8.After finishing of the study results will be published.