Key result
Higher mid-life FEV1 is linked to lower arterial stiffness, outperforming later-life lung function measures.
Why the study?
Increased arterial stiffness predicts future cardiovascular disease and its relationship with lung function measured in mid-life versus later life was unclear.
Does mid-life lung function predict arterial stiffness more strongly than later-life lung function in men?
Cohort (n=827)
Does mid-life lung function predict arterial stiffness more strongly than later-life lung function in men?
Effect estimate: beta coeff. -0.65 (95% CI -1.04, -0.26)
p-value: p=< 0.0001
Mid-life lung function is a stronger predictor of future arterial stiffness than later-life lung function in men, suggesting early developmental factors may influence both.
May inform timing of lung function monitoring for vascular risk in men; extends observational data but leaves causal pathways and screening utility open.
BACKGROUND: Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). METHODS: Men aged 47-67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n = 827) as well as having carotid-femoral pulse wave velocity (PWV) measured. RESULTS: Both forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P < 0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV(1) mid-life beta coeff. -0.65, 95% CI -1.04, -0.26, P < 0.0001; FVC mid-life beta coeff. -0.52, 95% CI -0.82, -0.23, P < 0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. CONCLUSIONS: Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease.
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Bolton et al. (2009) conducted a cohort in Arterial stiffness (n=827). Mid-life lung function vs. Later life lung function was evaluated on Carotid-femoral pulse wave velocity (PWV) (beta coeff. -0.65, 95% CI -1.04, -0.26, p=< 0.0001). Mid-life FEV1 was inversely associated with arterial stiffness (beta coeff. -0.65; 95% CI -1.04 to -0.26; P<0.0001), remaining a stronger predictor than later life lung function measures.
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