Lysis of rat erythrocytes by aqueous dispersions containing lysophosphatidylcholine (lpc), phosphatidylcholine (pc) and progesterone has been studied. The haemolytic activity of lpc was reduced by saturating it with progesterone; mixed lpc-pc micelles owed their lytic activity to the lpc alone. Cholesterol solubilized together with progesterone by lpc greatly reduced the lytic activity of the lpc, and when solubilized with progesterone by a 1:1 mixture of lpc and pc, prevented haemolysis. Triolein also inhibited the haemolytic properties of the sols.
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Kellaway et al. (1969) studied this question.
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