Brain Radiation Necrosis Outside the Target Volume After Proton Radiation Therapy: Analyses of Multiparametric Imaging and Proton Biologic Effectiveness

Meningiomas account for about one third of adult primary brain tumors. Although most meningiomas are benign, their intracranial location and corresponding risk of complications from therapy may cause life-threatening morbidity.1 Radiation therapy (RT) after surgical resection is often recommended to reduce the risk of local failure in patients with recurrent or higher-grade disease.2