Key result
Unexplained bilateral pleural effusion may signal early blast crisis in CML.
Why the study?
Pleural effusion in chronic myeloid leukemia is rarely reported and its correlation with blast crisis is unknown.
Case Report (n=1)
No
Bilateral pleural effusion may serve as an atypical early indicator of blast crisis onset in patients with chronic myeloid leukemia.
May prompt blast crisis evaluation in CML with unexplained pleural effusion; hypothesis-generating case report requiring prospective validation.
Pleural effusion in chronic myeloid leukemia (CML) has been rarely reported in medical practice.Additionally, the correlation of pleural effusion with blast crisis is unknown.This study reported a 66-year-old male patient who was diagnosed with bilateral pleural effusion three months before the blast transformation.Bilateral pleural effusion spontaneously resolved before the blast transformation.The cause of pleural effusion was unknown.Bilateral pleural effusion caused by unknown or known factors, except for that induced by drugs, is a poor prognostic marker for CML and is an unusual indicator of blast crisis.The presentation of the study case indicates that bilateral pleural effusion is an atypical and discernible early indicator of blast crisis onset in patients with CML.
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Erdinc et al. (2025) conducted a case report in Chronic Myeloid Leukemia (n=1). Bilateral pleural effusion was evaluated on Blast crisis onset. Bilateral pleural effusion of unknown etiology may serve as an atypical early indicator of blast crisis onset in patients with chronic myeloid leukemia.
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