Key result
Diffuse reflectance spectroscopy estimates blood fraction and oxygen saturation changes in brain tissue.
Why the study?
Continuous measurement of local brain oxygen saturation is important for monitoring brain trauma patients, but current micro-oxygen-electrodes have slow response times.
Diffuse reflectance spectroscopy can estimate blood fraction and oxygen saturation changes in brain tissue, offering a potential alternative to slow-responding micro-oxygen-electrodes.
Answers are grounded in this paper and cite their sources.
Offers preclinical proof-of-concept for cerebral monitoring; leaves open translation to human neurocritical care.
Continuous measurement of local brain oxygen saturation (SO2) can be used to monitor the status of brain trauma patients in the neurocritical care unit. Currently, micro‐oxygen‐electrodes are considered as the “gold standard” in measuring cerebral oxygen pressure (pO2), which is closely related to SO2 through the oxygen dissociation curve (ODC) of hemoglobin, but with the drawback of slow in response time. The present study suggests estimation of SO2 in brain tissue using diffuse reflectance spectroscopy (DRS) for finding an analytical relation between measured spectra and the SO2 for different blood concentrations. The P3 diffusion approximation is used to generate a set of spectra simulating brain tissue for various levels of blood concentrations in order to estimate SO2. The algorithm is evaluated on optical phantoms mimicking white brain matter (blood volume of 0.5–2%) where pO2 and temperature is controlled and on clinical data collected during brain surgery. The suggested method is capable of estimating the blood fraction and oxygen saturation changes from the spectroscopic signal and the hemoglobin absorption profile. magnified image
No takes yet. Share an insight, caveat, or question.
Rejmstad et al. (2016) studied Brain trauma / brain surgery. Diffuse reflectance spectroscopy (DRS) was evaluated on Estimation of blood fraction and oxygen saturation changes. Diffuse reflectance spectroscopy (DRS) is capable of estimating blood fraction and oxygen saturation changes from the spectroscopic signal and hemoglobin absorption profile in brain tissue.
Synapse has enriched 10 related papers. Consider them for comparative context: