Aphanamenes A (1) and B (2), two unprecedented acyclic diterpene dimers formed via a [4 + 2]-cycloaddition, were isolated from the root bark of Aphanamixis grandifolia. Their structures were elucidated by spectroscopic analyses, and the absolute configuration of 1 was determined by ECD calculations. Both 1 and 2 showed significant inhibition on NO production on lipopolysaccharide-induced RAW264.7 macrophages.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: