Imidazole and Trifluoroethanol as Efficient and Mild Reagents for Destruction of Excess Di-tert-butyl Dicarbonate [(BOC)2O]

All articles of this category Mild and efficient procedures employing inexpensive reagents (imidazole or trifluoroethanol) for the removal of excess (BOC) 2 O, usually used during NH or OH protection at room temperature, are described. The use of polymer-based DMAP with or without TFE was also found to be attractive. (BOC) 2 O excess - imidazole (Im) - trifluoroethanol (TFE) - DMAP - polyDMAP