Key result
N-methyl berbamine extends action potential durations and inhibits L-type Ca2+ and hERG K+ channel currents.
Why the study?
The pharmacological effects of N-methyl berbamine, a berberine derivative with potential antiarrhythmic properties, are ill-defined.
N-methyl berbamine acts as a multitarget antiarrhythmic agent by blocking both calcium and potassium channel currents, thereby extending action potential duration.
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Hypothesis-generating for multitarget antiarrhythmics; leaves open translation to clinical arrhythmia management.
Hu et al. (2019) studied this question. N-methyl berbamine (N-MB) was evaluated on Effects on action potential and ionic currents (CaV1.2 Ca2+ and KV11.1 K+ channels). N-methyl berbamine extended action potential durations and inhibited both L-type Ca2+ and hERG K+ channel currents in ventricular myocytes and transfected cells.