Key result
Carotid body chemoreceptors may sense systemic inflammation to act as an afferent anti-inflammatory reflex arm.
Why the study?
The role of carotid body inflammation in sensing systemic inflammatory molecules and its involvement in hypoxia and the anti-inflammatory reflex is emerging but not fully understood.
This review highlights the emerging role of the carotid body as a sensor of systemic inflammation and its involvement in the anti-inflammatory reflex and hypoxic responses.
Hypothesizes carotid body as inflammation sensor; leaves open any therapeutic role pending prospective validation.
Emergent evidence indicates that the carotid body (CB) chemoreceptor may sense systemic inflammatory molecules and is an afferent arm of the anti-inflammatory reflex. Moreover, a proinflammatory milieu within the CB is involved in the enhanced CB chemosensory responsiveness to oxygen following sustained and intermittent hypoxia. In this review, we focus on the physiopathological participation of CBs in inflammatory diseases, such as sepsis and intermittent hypoxia.
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Iturriaga et al. (2021) conducted a review in Inflammatory diseases (sepsis, intermittent hypoxia). Carotid body inflammation and hypoxia was evaluated. The carotid body chemoreceptor may sense systemic inflammatory molecules and act as an afferent arm of the anti-inflammatory reflex, with inflammation enhancing responsiveness to hypoxia.
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