Key result
Lower circulating EPCs in female SLE patients are linked to pathological arterial stiffness.
Why the study?
Decreased circulating endothelial progenitor cells have been suggested to be associated with increased subclinical atherosclerosis, but their relationship in SLE patients was unclear.
Is a decreased number of circulating endothelial progenitor cells associated with subclinical atherosclerosis and cardiovascular risk factors in female patients with systemic lupus erythematosus?
Comparison
Patients with pathological versus normal pulse wave velocity
Design
Cross-sectional study with flow cytometry and vascular imaging
Authors
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Hypothesis-generating for EPCs as subclinical atherosclerosis biomarker in female SLE; prospective validation required before clinical adoption.
Cross-Sectional (n=46)
Is a decreased number of circulating endothelial progenitor cells associated with subclinical atherosclerosis and cardiovascular risk factors in female patients with systemic lupus erythematosus?
Decreased circulating endothelial progenitor cells are associated with pathological arterial stiffness and cardiovascular risk factors in female SLE patients, suggesting their potential as a biomarker for subclinical atherosclerosis.
Castejón et al. (2013) conducted a cross-sectional in Systemic lupus erythematosus (n=46). Decreased circulating endothelial progenitor cells vs. Normal circulating endothelial progenitor cells was evaluated on Pathological arterial stiffness (pulse wave velocity). Decreased circulating endothelial progenitor cells in female SLE patients were significantly associated with pathological arterial stiffness and cardiovascular risk factors.
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