Key result
HCM mice show ~19% lower resting myocardial perfusion at end-diastole versus healthy controls.
Why the study?
Hypertrophic cardiomyopathy related myocardial vascular remodelling may reduce myocardial blood supply and cause progressive cardiac dysfunction, but this process has been difficult to observe and its connection remains unclear.
Can cine ASL-CMR detect microvascular dysfunction and myocardial remodeling in a mouse model of hypertrophic cardiomyopathy?
Comparison
DBA/2J HCM model vs C57BL/6J reference strain
Design
Preclinical study with blinded data analysis using cine ASL-CMR and histology
Authors
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Suggests microvascular dysfunction in HCM models; hypothesis-generating and requires human validation before clinical relevance.
Can cine ASL-CMR detect microvascular dysfunction and myocardial remodeling in a mouse model of hypertrophic cardiomyopathy?
Absolute Event Rate: 7.5% vs 9.3%
p-value: p=<0.05
Cine ASL-CMR can non-invasively detect resting myocardial microvascular dysfunction and its association with hypertrophy and fibrosis in a mouse model of hypertrophic cardiomyopathy.
Ku et al. (2021) studied Hypertrophic cardiomyopathy (n=36). DBA/2J (D2) mouse strain with spontaneous HCM variants vs. C57BL/6J (B6) reference strain was evaluated on Resting global myocardial perfusion (myocardial blood flow) at end-diastole (p=<0.05). In a mouse model of hypertrophic cardiomyopathy, resting global myocardial perfusion at end-diastole was significantly lower in D2 mice compared to B6 reference mice (7.5 vs 9.3 ml/g/min, p<0.05).
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