Synthesis and Anticonvulsant Studies of Thiazolidinone and Azetidinone Derivatives from Indole Moiety

2-Amino-5-(3'-indolomethylene)-1, 3 , 4 - oxadiazole (3): undergoes facile condensation with various aromatic aldehydes to gave 2-substitiuted arylidenylamino-5-(3'- indolomethylene) - 1, 3 , 4 - oxadiazole (4-8): . Cyclocondensation of (4-8): with thioglycolic acid and triethylamine yielded 3-[5'-(3"- indolomethylene)- 1', 3', 4'- oxadiazol-2'-yl]- 2- (substituted aryl)-4- thiazolidinones (9-13): and 1-[5'-(3"- indolomethylene) -1', 3', 4'- oxadiazol - 2'- yl ] -4-(substituted aryl) -2- azetidinones (14-18): . The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesised compounds were evaluated for their anticonvulsant activity and acute toxicity.