A vanadium-mediated pinacol coupling reaction was the key step in the synthesis of the polyene macrolactam (9S,18R)-cyclamenol A (1). The natural diastereomer (configuration not known) inhibits the adhesion of leukocytes to endothelial cells, a key event in the response to inflammation, tissue injury, and infection.
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Nazaré et al. (2000) studied this question.