A Novel Approach Towards cis- and trans-Fused Pyranopyrans Based on Ring-Closing Metathesis Reaction of Carbohydrate Derivatives

All articles of this category A novel synthesis of both cis- and trans- fused pyranopyran systems, based on ring-closing metathesis of glycal derived dienes, is described. Isomerisation of the resulting allylic double bond provides a new cyclic enol ether, thus opening the way to an iterative synthesis of cis -( trans- )fused cyclic polyethers. glycals - ring-closing metathesis - fused oxacycles