Hot off the breath: ‘I've a cost for’—the 64 million dollar question: Table 1

obliterative process in the smallest of the conducting airways and the inflammatory/ fibrotic process that thickens and narrows the larger airways that are visible on CT.In summary, the results of Martinez et al 1 raise important questions about the relationship between structural changes in the lung, abnormalities of lung function and respiratory related symptoms, physical activity and psychosocial impacts.It is somewhat paradoxical that the authors chose to compare more precise morphological features of COPD with composite measures of function and symptoms since the COPD community is striving to separate subphenotypes of COPD based on pathogenetic mechanisms and structural changes.However, by identifying the relationships between these CT features and the components of the composite scores, the authors have allowed us to more precisely determine their relationship to CT features and in so doing have raised important issues.