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Vasoactive intestinal polypeptide (VIP) antiserum, alpha-chymotrypsin, and repeated exposure to VIP markedly reduced relaxations of the mouse anococcygeus muscle to VIP but not to field stimulation. This evidence suggests that VIP does not mediate non-adrenergic, non-cholinergic relaxations in the mouse anococcygeus.
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Carvajal et al. (1986) studied this question.
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