Key result
PON2 overexpression reduces ovarian tumor weight ~37% versus controls in a mouse xenograft model.
Why the study?
The role of Paraoxonase 2 (PON2) in ovarian cancer development remains unknown despite its known antioxidant properties and impact on mitochondrial ROS.
Does PON2 overexpression prevent tumor formation in a mouse model of ovarian cancer?
Population
Mouse xenograft model of ovarian cancer and human ovarian cancer tissue
Comparison
PON2 overexpression vs normal tissue or control
Design
Preclinical experimental study
Authors
Loading...
Attenuates ovarian xenograft tumor growth; leaves open whether PON2 is a viable therapeutic target in patients.
Does PON2 overexpression prevent tumor formation in a mouse model of ovarian cancer?
Absolute Event Rate: 32% vs 51%
p-value: p=<0.01
PON2 acts as a tumor suppressor in early-stage ovarian cancer by reducing mitochondrial superoxide generation and IGF-1 signaling, suggesting a potential therapeutic target.
Devarajan et al. (2018) studied Ovarian cancer (n=30). Paraoxonase 2 (PON2) overexpression vs. Empty vector (ID8 EV) was evaluated on Tumor weight (mg) (p=<0.01). Overexpression of human PON2 in a mouse xenograft model of ovarian cancer significantly reduced tumor weight (32 vs 51 mg) and volume compared to empty vector controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: