Key result
Asymptomatic autonomic neuropathy in diabetics is linked to a normalized fibrinolytic response to stimulation.
Why the study?
In diabetes mellitus, the vascular endothelium often produces abnormally low amounts of plasminogen activator, leading to impaired fibrinolytic activity that may contribute to angiopathy development.
Does asymptomatic autonomic neuropathy affect fibrinolytic response in patients with diabetes mellitus?
Observational
Does asymptomatic autonomic neuropathy affect fibrinolytic response in patients with diabetes mellitus?
Asymptomatic autonomic neuropathy in diabetes may normalize impaired fibrinolytic activity, potentially modifying the development of angiopathy.
May normalize fibrinolysis in diabetic autonomic neuropathy; hypothesis-generating and leaves open any effect on angiopathy risk.
In diabetes mellitus the vascular endothelium often produces and releases abnormally low amounts of plasminogen activator, leading to an impaired fibrinolytic system, which might be of importance for the development of angiopathy. In this study tests of autonomic neuropathy (AN) were performed on diabetics without autonomic symptoms. It was discovered that diabetics without AN had a significantly lower mean fibrinolytic response to stimulation than nondiabetic controls, whereas this reduction was not found in those with AN. The suggestion that asymptomatic AN might induce a normalization of the impaired fibrinolytic system in diabetes, and thus have a modifying effect on the rate of development of angiopathy, requires further study to be properly evaluated.
No takes yet. Share an insight, caveat, or question.
Almér et al. (1983) conducted an observational in Diabetes Mellitus. Autonomic neuropathy (asymptomatic) vs. Diabetics without autonomic neuropathy and nondiabetic controls was evaluated on Mean fibrinolytic response to stimulation. Asymptomatic autonomic neuropathy in diabetics was associated with a normalized fibrinolytic response to stimulation, whereas diabetics without autonomic neuropathy had a significantly lower response.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: