Osteopenia and decreased bone formation in osteonectin-deficient mice

Figure 5 Trabecular bone-formation rate in tibiae of control (+/+) and osteonectin-null (-/-) mice.In vivo dual calcein labeling allows an estimate of bone-formation rate, which considers the distance between 2 fluorescent labels.Representative data from 11-week-old control (a) and osteonectin-null (b) mice are shown.Bars show mean ± SEM (n ≥ 4).A P < 0.01 between control and mutant mice, as determined by 2-way ANOVA.