Early onset colorectal cancer: Challenges across the cancer care continuum

Early Onset Colorectal cancer (EOCRC) incidence is increasing at an alarming pace. An increase of 90% in colon cancer and 124% in rectal cancer is expected by 2030. Patients with EOCRC are not receiving additional attention compared to older patients despite having a unique molecular pattern, majority of cases are sporadic, and related short- and long-term treatment and disease complications. The current management and screening guidelines have been constructed from studies on late onset CRC. Plethora of studies are ongoing to understand this disease entity in order to construct a tailored prevention, detection and management plans. While waiting for a better understanding of the disease, efforts should be directed toward improving the quality of care across the cancer continuum. Here we aim to address the challenges faced by EOCRC patients across the cancer continuum. This will facilitate directing future efforts and research toward construction of a personalized and precise guidelines. HIGHLIGHTS Studies showed that Ealy onset colorectal cancer is caused by an accumulative risk exposure. Indirect cost of premature death and reduced productivity due to EOCRC exceeds direct costs. Patients, system and physicians related diagnosis delays should be improved. Young cancer patients have unique survivorship concerns different from old patients.