Key result
Newly generated hiPSC line enables in vitro disease modeling of primary progressive multiple sclerosis.
Why the study?
Options remain limited for people with primary progressive multiple sclerosis, necessitating disease-specific models for study.
The generation of this disease-specific hiPSC line provides a useful in vitro model for studying primary progressive multiple sclerosis.
Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease that results in immune cell infiltration of the central nervous system (CNS) and demyelination in young adults. Substantial progress has been made in developing disease modifying therapies for people with relapsing-remitting MS, but options remain limited for people with primary progressive MS (PPMS). PPMS accounts for ∼15% of MS diagnoses. Herein, we generated a human induced pluripotent stem cell line (hiPSC) from a person with clinically definite PPMS. This disease-specific hiPSC line will be useful for studying PPMS in vitro, allowing the generation of immune and CNS cell types.
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Mehta et al. (2021) studied Primary progressive multiple sclerosis (n=1). Generation of human induced pluripotent stem cell line (MNZTASi001-A) was evaluated on Generation of hiPSC line. A human induced pluripotent stem cell line (MNZTASi001-A) was successfully generated from a person with clinically definite primary progressive multiple sclerosis for in vitro disease modeling.
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