Key result
DRB1*14-DQB1*0301 haplotype linked to ~74% lower risk of T. cruzi infection.
Why the study?
The role of HLA class II gene polymorphisms in susceptibility to Trypanosoma cruzi infection and chagasic heart disease was unclear in a rural mestizo population.
Does the HLA-DRB1*14-DQB1*0301 haplotype protect against Trypanosoma cruzi infection and chagasic heart disease in an endemic population?
Case-Control (n=172)
No
Does the HLA-DRB1*14-DQB1*0301 haplotype protect against Trypanosoma cruzi infection and chagasic heart disease in an endemic population?
Odds Ratio: 0.26
p-value: p=0.01
The HLA-DRB1*14-DQB1*0301 haplotype is associated with a reduced susceptibility to chronic Trypanosoma cruzi infection in an endemic Peruvian population.
Haplotype may indicate protection from T. cruzi in endemic areas; leaves open prospective validation before any screening or prevention implications.
We explored a possible role of HLA class II genes in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease in a rural mestizo population from Arequipa (Southern Peru). HLA-DRB1 and DQB1 polymorphisms were determined in 85 seropositive (asymptomatic, n=52; cardiomyopathic, n=33) and 87 seronegative individuals. We observed that the DRB1*14-DQB1*0301 haplotype correlates with not having T. cruzi infection in a highly endemic area (OR= 0.26 (0.124.63); Pc=0.01). This protective association is a dominant trait. We found no differences in the allelic or haplotypic distributions we examined between asymptomatic and cardiomyopathic patients in this population. Our data offer indirect but compelling evidence that polymorphism in HLA region is involved in a differential susceptibility to T. cruzi chronic infection.
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Nieto et al. (2000) conducted a case-control in Trypanosoma cruzi infection (n=172). DRB1*14-DQB1*0301 haplotype vs. Absence of haplotype was evaluated on Not having T. cruzi infection (OR 0.26, 95% CI 0.124.63, p=0.01). The DRB1*14-DQB1*0301 haplotype was significantly associated with a lower likelihood of having T. cruzi infection (OR 0.26; Pc=0.01).
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