Hepatitis and ketoconazole therapy

SIR,-The interesting research of ProfessorA G Shaper and others (18 July, p 179) assessing cardiovascular risk factors in middleaged men attempted to define the contribution of alcohol intake on the basis of the answers to three questions.They indicate that measurements on the population sampled included a full haematological study.It would be interesting to know what the correlation was between mean cell volumes and defined heavy drinking.Any such correlation would be further evidence for the usefulness of estimations of mean cell volumes,' and could point to their use as population screening instruments.