Increased amyloid production from aberrant beta-amyloid precursor proteins.

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells1992 · 145 citations
2. 2Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.1993 · 570 citations
3. 3Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.1993 · 151 citations
4. 4beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.1993 · 466 citations