Further bioactivity-guided fractionation of a chloroform extract of the twigs of Agrostistachys hookeri against cultured P-388 lymphocytic leukemia cells, has led to the isolation of a cytotoxic ellagic acid derivative, 3,3′,4- O -trimethylellagic acid ( 1 ), and three inactive compounds, consisting of a new compound, 3,4,5,5′- O -tetramethyl-3′,4′- O,O -methylidenecoruleoellagic acid ( 2 ), and the known compounds, 3,4,5- O -trimethyl-3′,4′- O,O -methylideneflavellagic acid ( 3 ) and betulinic acid. The structure of the novel coruleoellagic acid derivative ( 2 ) was established by comparison of its spectral parameters with those of known ellagic acid derivatives.
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Choi et al. (1988) studied this question.