A convenient one-pot process for preparing various esters of caffeic acid from 3,4-dihydroxybenzaldehyde has been developed. The alcohols or phenols react with Meldrum's acid to form malonic acid mono-esters, which, without separating, immediately react with 3,4-dihydroxybenzaldehyde to afford the desired esters in good yield. The 1 H NMR data and X-ray diffraction analyses indicate that these α,β-unsaturated esters are in trans ( E) form in accord with natural esters.
No takes yet. Share an insight, caveat, or question.
Hu et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: