Samples of equimass fraction chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer with and without gradient concentration of amoxicillin, a topical antibiotic drug were prepared via traditional casting techniques. Changing in antibacterial activity and swelling degree have been assessed using the zone of inhibition method and pH sensitivity study. Upon increasing the amoxicillin concentration, the enhancement of antibacterial activity was performed against (2g) positive bacteria (S. aureus, B. subtilis), (2g) negative bacteria (E. coli, P. aeuroginosa) and fungus (C. albicans). Increasing the concentration of amoxicillin caused a decreasing in the swelling ratio (SR) at neutral (pH= 7) and basic medium (pH= 8, 9) due to increase cross-linked and rigidity of the network. Hence the results strongly support the possibility of using this novel Cs/PVA/SA with different amounts of amoxicillin to compatible used in tissue regeneration and antimicrobial applications.
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