Key result
Brain blood flow tightly couples to activity via short-term vasoactive factors and long-term capillary density.
Why the study?
Functional activity, metabolism, and blood flow in the brain are locally heterogeneous but tightly coupled through short-term and long-term mechanisms, requiring distinction between apparent and real uncoupling.
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Design
Review
Recognizing short-term and long-term mechanisms of blood flow regulation in the brain permits the distinction between apparent and real uncoupling of function, metabolism, and blood flow.
Functional activity, metabolism, and blood flow in the brain, although locally heterogeneous, are tightly coupled. Blood flow is adjusted to local activity in two ways: 1) short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation;and 2) long-term, static coupling apparently mediated by changes in capillary density. Recognizing these two mechanisms permits one to distinguish apparent from real uncoupling.
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Wolfgang Kuschinsky (1987) reported a review. Blood flow in the brain is tightly coupled to functional activity and metabolism through short-term dynamic regulation by vasoactive factors and long-term static regulation via capillary density.
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