Green Monkey Disease ("Marburg Virus" Disease): A New Zoonosis

Editorials1 September 1969Green Monkey Disease ("Marburg Virus" Disease): A New ZoonosisJAMES P. LUBY, M.D., CHARLES V. SANDERS, M.D.JAMES P. LUBY, M.D., CHARLES V. SANDERS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-3-657 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring August and September 1967, an epidemic of a previously undescribed human disease occurred which was related to contact with African green monkeys (Cercopithecus aethiops) (1-8). In total, there were 31 cases in 3 European cities: 23 in Marburg, 6 in Frankfurt, and 2 in Belgrade. Nine deaths resulted with a case-fatality-ratio of 29%. Twenty-six of the cases were in laboratory workers having direct contact with blood or tissues of these animals. Four cases were in hospital personnel caring for the patients; infection in these instances most probably was incurred through contact with the patients' blood. A single case probably...References1. MARTINIKNAUFFSCHMIDTMAYERBALTZER GAHGHAGG: A hitherto unknown infectious disease contracted from monkeys. "Marburg-virus" disease. [Ger.] German Med. Monthly 13: 457, 1968. MedlineGoogle Scholar2. STILLEBÖHLEHELMVAN REYSIEDE WEEWW: An infectious disease transmitted by Cercopithecus aethiops. "Green monkey disease." [Ger.] German Med. Monthly 13: 470, 1968. MedlineGoogle Scholar3. Morbidity and Mortality Weekly Report. National Communicable Disease Center, vol. 16, No. 36, United States Public Health Service. September 9, 1967. Google Scholar4. Ibid., No. 37, September 16, 1967, p. 316. Google Scholar5. Ibid., No. 38, September 23, 1967, p. 324. Google Scholar6. Ibid., No. 39, September 30, 1967, p. 332. Google Scholar7. Ibid., No. 42, October 21, 1967, p. 353. Google Scholar8. Ibid., No. 43, October 28, 1967, p. 361. Google Scholar9. HELDRICHARDSONMOSLEY JRJHJ: A zoonosis associated with African green monkeys. J. Amer. Vet. Med. Ass. 153: 881, 1968. MedlineGoogle Scholar10. GEDIGKBECHTELSHEIMERKORB PHG: The morbid anatomy of Marburg virus disease. [Ger.] German Med. Monthly 14: 68, 1969. MedlineGoogle Scholar11. SIEGERTSHUSLENCZKA RHLW: Isolation and identification of the "Marburg virus". [Ger.] German Med. Monthly 13: 514, 1968. MedlineGoogle Scholar12. MAYKNOTHE GH: Bacteriological and virological investigations of infections transmitted from monkeys to man in Frankfurt/Main. [Ger.] Ibid., p. 518. Google Scholar13. SIEGERTSHUSLENCZKA RHLW: Detection of the "Marburg virus" in patients. [Ger.] Ibid., p. 521. Google Scholar14. GORDON SMITHSIMPSONBOWENZLOTNIK CEDIETI: Fatal human disease from vervet monkeys. Lancet 2: 1119, 1967. CrossrefMedlineGoogle Scholar15. KISSLINGROBINSONMURPHYWHITFIELD RERQFASG: Agent of disease contracted from green monkeys. Science 160: 888, 1968. CrossrefMedlineGoogle Scholar16. SLENCZKASHUPIEPENBURGSIEGERT WHLGR: Detection of the antigen of the "Marburg virus" in the organs of infected guinea-pigs by immunofluorescence. [Ger.] German Med. Monthly 13: 524, 1968. MedlineGoogle Scholar17. Multiauthored: Care and diseases of the research monkey. Ann. NY Acad. Sci. 85: 735, 1960. Google Scholar18. Editorial: Cell substrates for virus vaccines. Lancet 2: 1342, 1967. MedlineGoogle Scholar19. IKIĆJANČIKIĆBRANICAMANHALTER DBMT: The safety of human diploid cell strains for man: a controlled study of symptoms occurring after the administration of WM-3 living attenuated poliovirus vaccine prepared in the WI-38 human diploid cell strain. Amer. J. Epidem. 87: 411, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES P. LUBY, M.D.; CHARLES V. SANDERS, M.D.Affiliations: Department of Internal Medicine University of Texas Southwestern Medical School at Dallas Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathogenicity and virulence of Marburg virusA hybrid resampling algorithms SMOTE and ENN based deep learning models for identification of Marburg virus inhibitorsHigh-Throughput Screening Assay to Identify Small Molecule Inhibitors of Marburg Virus VP40 ProteinThe Causal Relationship between Eating Animals and Viral EpidemicsMarburg virus disease outbreak in Kween District Uganda, 2017: Epidemiological and laboratory findingsNeurological Complications of Ebola Virus InfectionEbola VirusEmerging and Reemerging Infectious Disease ThreatsThe 2014 Ebola Virus Outbreak in West Africa: Current Perspectives for Prevention and TreatmentPotential for Introduction of Bat-Borne Zoonotic Viruses into the EU: A ReviewFilovirus infectionsManaging Potential Laboratory Exposure to Ebola Virus by Using a Patient Biocontainment Care Unit1Virus Research 1 September 1969Volume 71, Issue 3Page: 657-660KeywordsBloodResearch laboratoriesZoonoses ePublished: 1 December 2008 Issue Published: 1 September 1969 PDF downloadLoading ...