Key result
IV defibrotide is associated with improved rheological parameters and decreased reactive hyperemia times in POAD.
Why the study?
The effects of Defibrotide on rheological and peripheral haemodynamic parameters in POAD patients were investigated to assess its activity beyond fibrinolysis.
Does intravenous defibrotide improve rheological and haemodynamic parameters in patients with POAD?
Does intravenous defibrotide improve rheological and haemodynamic parameters in patients with POAD?
Intravenous defibrotide improves rheological parameters and reactive hyperemia in patients with peripheral obstructive arterial disease.
Defibrotide may enhance microcirculation in POAD; leaves open effects on clinical outcomes.
In ten POAD patients, 800 mg. of Defibrotide (polideoxynucleotide extracted from mammalian lung, with antitrombotic and fibrinolytic activity) were infused i.v. Blood and plasma viscosity, haematocrit, blood filterability and fibrinogen concentration were controlled, in basal conditions and after one hour from the end of infusion. Haemodynamic parameters: rest flow, peak flow, time to peak flow, half time and total time of reactive hyperemia by means of strain gauge pletismography, were controlled at lower limbs before infusion and after 1 h., 2 h., 6 h., from the end of infusion. The present investigation showed an improvement of rheological parameters and a decrease of total time and half time of reactive hyperemia. These data demonstrate a rheological activity of Defibrotide as well as the fibrinolytic one.
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Cappelli et al. (1987) studied Peripheral Obstructive Arterial Disease (POAD) (n=10). Defibrotide vs. Basal conditions (pre-infusion) was evaluated on Rheological parameters and haemodynamic parameters (reactive hyperemia). Intravenous infusion of 800 mg of defibrotide in POAD patients improved rheological parameters and decreased the total and half time of reactive hyperemia.
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