Key result
Drugs in pregnancy and lactation lack sufficient PK/PD data to guide informed selection and dosing.
Why the study?
There are very few studies examining pharmacokinetics and pharmacodynamics in women during pregnancy and lactation despite known physiologic changes affecting these measures.
What are the pharmacokinetics and pharmacodynamics of drugs commonly used in pregnancy and parturition?
What are the pharmacokinetics and pharmacodynamics of drugs commonly used in pregnancy and parturition?
There is a significant lack of information regarding the pharmacokinetics and pharmacodynamics of drugs in pregnancy and lactation, which complicates proper medication selection and dosing.
Requires cautious dosing in pregnancy and lactation; leaves open critical gaps for dedicated PK/PD studies.
(Abstracted from Anesth Analg, 122:786–804, 2016) There are very few studies that examine pharmacokinetics and pharmacodynamics in women during pregnancy and lactation, despite the fact that pregnancy is known to induce physiologic changes that may affect these measures. This lack of information makes it difficult for physicians and patients to make informed decisions regarding proper selection and dosing of medications.
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Ansari et al. (2016) conducted a review in Pregnancy and lactation. Drugs commonly used in pregnancy and parturition was evaluated. Pharmacokinetics and pharmacodynamics of drugs in pregnancy and lactation lack sufficient study, making it difficult to make informed decisions regarding proper selection and dosing.
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