Background: This study aimed to assess the effectiveness of exercise intervention in reducing body weight and glycosylated hemoglobin (HbA1c) level in patients with type 2 diabetes mellitus (T2DM) in Korea.Methods: Cochrane, PubMed, Embase, KoreaMed, KMbase, NDSL, KCI, RISS, and DBpia databases were used to search randomized controlled trials and controlled clinical trials that compared exercise with non-exercise intervention among patients with non-insulin-treated T2DM in Korea.The effectiveness of exercise intervention was estimated by the mean difference in body weight changes and HbA1c level.Weighted mean difference (WMD) with its corresponding 95% confidence interval (CI) was used as the effect size.The pooled mean differences of outcomes were calculated using a random-effects model.Results: We identified 7,692 studies through literature search and selected 23 articles (723 participants).Compared with the control group, exercise intervention (17 studies) was associated with a significant decline in HbA1c level (WMD, -0.58%; 95% CI, -0.89 to -0.27;I 2 =73%).Although no significant effectiveness on body weight was observed, eight aerobic training studies showed a significant reduction in body weight (WMD, -2.25 kg; 95% CI, -4.36 to -0.13;I 2 =17%) in the subgroup analysis.Conclusion: Exercise significantly improves glycemic control; however, it does not significantly reduce body weight.Aerobic training can be beneficial for patients with non-insulin-treated T2DM in Korea.
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