Key result
Elevated CCL2 and CCL5 during pulmonary CMV predict BOS and higher mortality post-lung transplant.
Why the study?
Pulmonary CMV infection and disease are associated with reduced long-term survival post-lung transplantation, but the specific biologic mechanisms remain unclear.
Do altered levels of CC chemokines in BALF during pulmonary CMV predict BOS and mortality in lung transplant recipients?
Case-Control (n=72)
Do altered levels of CC chemokines in BALF during pulmonary CMV predict BOS and mortality in lung transplant recipients?
Elevated levels of specific CC chemokines (CCL2 and CCL5) in BALF during pulmonary CMV infection predict the development of BOS and increased mortality post-lung transplantation.
No takes yet. Share an insight, caveat, or question.
CMV-associated CC chemokine upregulation may mediate graft dysfunction; hypothesis-generating for targeted interventions in lung transplant.
Weigt et al. (2008) conducted a case-control in Pulmonary CMV post-lung transplantation (n=72). Pulmonary CMV infection and disease vs. Healthy lung transplant controls was evaluated on Development of bronchiolitis obliterans syndrome (BOS) and mortality. Elevated levels of CCL2 and CCL5 in bronchoalveolar lavage fluid during pulmonary CMV predicted the development of bronchiolitis obliterans syndrome and increased mortality post-lung transplant.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: