Key result
ETS-1 variant rs73013527 minor allele T linked to ~49% lower rheumatoid arthritis risk.
Why the study?
ETS-1 might correlate with rheumatoid arthritis susceptibility and development, but its role in the Chinese Han population is not clearly defined.
Are ETS-1 polymorphisms associated with rheumatoid arthritis susceptibility in the Chinese Han population?
Case-Control (n=350)
No
Are ETS-1 polymorphisms associated with rheumatoid arthritis susceptibility in the Chinese Han population?
Odds Ratio: 0.51 (95% CI 0.37–0.7)
Absolute Event Rate: 26.9% vs 41.9%
p-value: p=<0.001
The SNP rs73013527 in the ETS-1 gene is associated with rheumatoid arthritis susceptibility and disease activity in the Chinese Han population.
OBJECTIVE: E26 transformation specific sequence 1 (ETS-1) belongs to the ETS family of transcription factors that regulate the expression of various immune-related genes. Increasing evidence indicates that ETS-1 could contribute to the pathogenesis of autoimmune disease. Recent research has provided evidence that ETS-1 might correlate with rheumatoid arthritis (RA), but it's not clearly defined. In this study, we aimed to identify whether polymorphisms of ETS-1 play a role in Rheumatoid arthritis (RA) susceptibility and development in Chinese Han population. METHODS: Four single nucleotide polymorphisms (SNPs) within ETS-1 were selected based on HapMap data and previous associated studies. Whole blood and serum samples were obtained from 158 patients with RA and 192 healthy subjects. Genotyping was performed with polymerase chain reaction-high resolution melting (PCR-HRM) assay and the data was analyzed using SPSS17.0. RESULTS: A significantly positive correlation was observed between the SNP rs73013527 of ETS-1 and RA susceptibility, DAS28 and CRP (P<0.001, P = 0.001, and P = 0.028, respectively). Carriers of the haplotype CCT or TCT for rs4937333, rs11221332 and rs73013527 were associated with decreased risk of RA as compared to controls. No statistical significant difference was observed in the distribution of rs10893872, rs4937333 and rs11221332 genotypes between RA patients and controls. CONCLUSIONS: Our data further supports that ETS-1 has a relevant role in the pathogenesis and development of RA. Allele T of rs73013527 plays a protective role in occurrence of RA but a risk factor in the high disease activity. Rs10893872, rs11221332 and rs4937333 are not associated with RA susceptibility and clinical features.
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Chen et al. (2015) conducted a case-control in Rheumatoid Arthritis (n=350). ETS-1 polymorphism rs73013527 (Allele T) vs. Allele C (major allele) / Healthy controls was evaluated on Rheumatoid arthritis susceptibility (OR 0.51, 95% CI 0.37-0.70, p=<0.001). The minor allele T of the ETS-1 variant rs73013527 was significantly associated with a reduced risk of rheumatoid arthritis susceptibility (OR 0.51) in a Chinese Han population.
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