Key result
Pharmacological Ras inhibition decreases early fibrotic response in obstructed kidneys by reducing Ras/Erk/Akt signaling.
Why the study?
The effect of inhibiting angiotensin II receptors or Ras activation on early renal fibrotic changes induced by unilateral ureteral obstruction was assessed to explore potential prevention strategies for renal fibrosis.
Pharmacological inhibition of Ras activation via AT1 receptor blockade or Ras prenylation inhibitors reduces early renal fibrotic changes in a murine model of obstructive nephropathy.
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Hypothesis-generating for targeting Ras or angiotensin II pathways in early renal fibrosis; leaves open whether.
Rodríguez-Peña et al. (2014) studied Obstructive nephropathy. Losartan, atorvastatin, FTI L-744,832, or chaetomellic acid A vs. Untreated UUO animals was evaluated on Levels of activated Ras, phospho-ERK1/2, phospho-Akt, fibronectin, and α-smooth muscle actin. Pharmacological inhibition of Ras activation via AT1 receptor blockade or Ras prenylation inhibitors reduced Ras/Erk/Akt signaling and decreased the early fibrotic response in obstructed kidneys.
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