A Case of Evolutionary Hypopituitarism Following Traumatic Brain Injury in Infancy

The long-term clinical course of hypopituitarism resulting from traumatic brain injury in children is unclear. We here present a case involving a 31-year-old Japanese male with hypopituitarism caused by traumatic brain injury at the age of 5 months. His height velocity began to decrease around 3 years of age. At age 7, growth hormone and thyroid-stimulating hormone deficiencies were diagnosed. At age 10, hydrocortisone therapy was started, and testosterone enanthate therapy was needed at age 14. The secretion of anterior pituitary hormones gradually decreased. We should check endocrinological tests in patients with traumatic brain injury who have retarded growth.